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Review of renal carcinoma with t(6;11)(p21;q12) with focus on clinical and pathobiological aspects

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dc.contributor.authorKuroda, Naoto
dc.contributor.authorTanaka, Azusa
dc.contributor.authorSasak, Naomi
dc.contributor.authorIshihara, AkiraHistology and Histopathology, vol. 28, nº 6, (2013)
dc.contributor.authorMatsuura, Keiko
dc.contributor.authorMoriyama, Masatsugu
dc.contributor.authorNagashima, Yoji
dc.contributor.authorInoue, Keiji
dc.contributor.authorPetersson, Fredrik
dc.contributor.authorMartignoni, Guido
dc.contributor.authorMichal, Michal
dc.contributor.authorHes, Ondrej
dc.date.accessioned2018-05-15T12:03:20Z
dc.date.available2018-05-15T12:03:20Z
dc.date.issued2013
dc.description.abstractRecently, a new category of MiTF/TFE family translocation carcinomas of the kidney has been proposed. This category includes Xp11.2 renal cell carcinoma (RCC) and the t(6;11) RCC. These tumors share clinical, morphological, immunohistochemical and molecular genetic features. In this article, we review t(6;11) RCC. This tumor predominantly affects children and young adults. Macroscopically, the tumor generally forms a well circumscribed mass. Satellite nodules may be observed. Histologically, the tumor comprises large cells and small cells surrounded by basement membrane material. Immunohistochemically, tumor cells show nuclear immunolabeling for TFEB and usually express Cathepsin-K in the cytoplasm. Karyotyping detects the rearrangement between chromosome 6p21 and chromosome 11q12. Alpha-TFEB fusion can be detected by reverse transcriptase polymerase chain reaction (RTPCR) or fluorescence in situ hybridization (FISH). Most cases affecting children and young adults seem to be indolent, but some adult cases have presented with metastasis or caused death. As previously reported cases remain limited to date, further examination in a large scale study will be needed in order to elucidate clinical behavior and molecular characteristics.es
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dc.format.extent6es
dc.identifier.citationHistology and Histopathology, vol. 28, nº 6, (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/58402
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectRenal carcinoma with t(6;11)(p21;q12)es
dc.subjectTFEBes
dc.subjectCathepsin-Kes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleReview of renal carcinoma with t(6;11)(p21;q12) with focus on clinical and pathobiological aspectses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº 6 (2013)