Publication: Review of renal carcinoma with t(6;11)(p21;q12)
with focus on clinical and pathobiological aspects
Authors
Kuroda, Naoto ; Tanaka, Azusa ; Sasak, Naomi ; Ishihara, AkiraHistology and Histopathology, vol. 28, nº 6, (2013) ; Matsuura, Keiko ; Moriyama, Masatsugu ; Nagashima, Yoji ; Inoue, Keiji ; Petersson, Fredrik ; Martignoni, Guido ; Michal, Michal ; Hes, Ondrej
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Recently, a new category of MiTF/TFE
family translocation carcinomas of the kidney has been
proposed. This category includes Xp11.2 renal cell
carcinoma (RCC) and the t(6;11) RCC. These tumors
share clinical, morphological, immunohistochemical and
molecular genetic features. In this article, we review
t(6;11) RCC. This tumor predominantly affects children
and young adults. Macroscopically, the tumor generally
forms a well circumscribed mass. Satellite nodules may
be observed. Histologically, the tumor comprises large
cells and small cells surrounded by basement membrane
material. Immunohistochemically, tumor cells show
nuclear immunolabeling for TFEB and usually express
Cathepsin-K in the cytoplasm. Karyotyping detects the
rearrangement between chromosome 6p21 and
chromosome 11q12. Alpha-TFEB fusion can be detected
by reverse transcriptase polymerase chain reaction (RTPCR)
or fluorescence in situ hybridization (FISH). Most
cases affecting children and young adults seem to be
indolent, but some adult cases have presented with
metastasis or caused death. As previously reported cases
remain limited to date, further examination in a large
scale study will be needed in order to elucidate clinical
behavior and molecular characteristics.
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Citation
Histology and Histopathology, vol. 28, nº 6, (2013)
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