Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma

Molina Gallego, María Luisa; Martínez Pérez, Salvador; García Bernal, David; Valdor Alonso, Rut

Publication:
Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma

dc.contributor.author	Molina Gallego, María Luisa
dc.contributor.author	Martínez Pérez, Salvador
dc.contributor.author	García Bernal, David
dc.contributor.author	Valdor Alonso, Rut
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2024-07-04T11:21:20Z
dc.date.available	2024-07-04T11:21:20Z
dc.date.issued	2019-12-31
dc.description	© 2019 by the authors.This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Cancer. To access the final edited and published work see https://doi.org/ doi:10.3390/cancers12010102
dc.description.abstract	Glioblastoma (GB) has been shown to up-regulate autophagy with anti- or pro-oncogenic effects. Recently, our group has shown how GB cells aberrantly up-regulate chaperone-mediated autophagy (CMA) in pericytes of peritumoral areas to modulate their immune function through cell-cell interaction and in the tumor’s own benefit. Thus, to understand GB progression, the effect that GB cells could have on autophagy of immune cells that surround the tumor needs to be deeply explored. In this review, we summarize all the latest evidence of several molecular and cellular immunosuppressive mechanisms in the perivascular tumor microenvironment. This immunosuppression has been reported to facilitate GB progression and may be differently modulated by several types of autophagy as a critical point to be considered for therapeutic interventions.	es
dc.format	application/pdf	es
dc.format.extent	20	es
dc.identifier.citation	Cancers 2020, 12, 102
dc.identifier.doi	https://doi.org/10.3390/cancers12010102
dc.identifier.issn	Electronic: 2072-6694
dc.identifier.uri	http://hdl.handle.net/10201/142862
dc.language	eng	es
dc.publisher	MDPI
dc.relation	This study was funded mainly by Ministerio de Economia y Competitividad de España, MINECO SAF2015-73923-JIN, Agencia Estatal de Investigación/Fondos Europeos de Desarrollo Regional/ Union Europea (AEI/FEDER/UE). It was supported in part by funds from Seneca Foundation 20840/PI/18, ISCIII/Red de Terapia Celular, TERCEL (RD16/0011/0010 and RD16/0011/0001).	es
dc.relation.publisherversion	https://www.mdpi.com/2072-6694/12/01/102
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Autophagy	es
dc.subject	Chaperone-mediated autophagy	es
dc.subject	Tumor	es
dc.subject	Glioblastoma	es
dc.subject	Perivascular cells	es
dc.subject	Pericytes	es
dc.subject	Immunosuppressive	es
dc.subject	Tumor immune tolerance	es
dc.subject	Autophagy inhibitors	es
dc.title	Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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