Publication: Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma
Authors
Molina Gallego, María Luisa ; Martínez Pérez, Salvador ; García Bernal, David ; Valdor Alonso, Rut
item.page.secondaryauthor
item.page.director
Publisher
MDPI
publication.page.editor
publication.page.department
DOI
https://doi.org/10.3390/cancers12010102
item.page.type
info:eu-repo/semantics/article
Description
© 2019 by the authors.This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/.
This document is the Published version of a Published Work that appeared in final form in Cancer. To access the final edited and published work see https://doi.org/ doi:10.3390/cancers12010102
Abstract
Glioblastoma (GB) has been shown to up-regulate autophagy with anti- or pro-oncogenic effects. Recently, our group has shown how GB cells aberrantly up-regulate chaperone-mediated autophagy (CMA) in pericytes of peritumoral areas to modulate their immune function through cell-cell interaction and in the tumor’s own benefit. Thus, to understand GB progression, the effect that GB cells could have on autophagy of immune cells that surround the tumor needs to be deeply explored. In this review, we summarize all the latest evidence of several molecular and cellular immunosuppressive mechanisms in the perivascular tumor microenvironment. This immunosuppression has been reported to facilitate GB progression and may be differently modulated by several types of autophagy as a critical point to be considered for therapeutic interventions.
publication.page.subject
Citation
Cancers 2020, 12, 102
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/