Publication: Immunohistochemical study of a case of malignant
Müllerian mixed tumor in comparison with the activity
of normal uterine tissue
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Date
1989
Authors
Ohrnori, Takaaki
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A case of rnalignant Müllerian rnixed tumor
of the uterus, exhibiting a histology of heterologous
osteosarcornatous differentiation, is presented. Special
ernphasis is placed on the characteristic irnrnunohistochernical
reactivity of the tumor tissue in cornparison
with that of normal uterine tissue in the proliferative
phase. Keratin, cytokeratin, epithelial rnernbrane
antigen (EMA), carcinoernbryonic antigen (CEA), and
hurnan chorionic gonadotropin (HCG) were found only
in the carcinornatous elernent. However, neuron specific
enolase (NSE), S-100 protein (S 100) and virnentin were
identified in alrnost al1 tumor tissue elernents. Desrnin
and actin were not stained in any elernents. Myoglobin
was only detected weakly in the squamous carcinornatous
elernent. Undifferentiated cell elernent, cornposed of
srnall, round, spindle, or polygonal cells showed positive
reactions to NSE and S 100, but not to any other
antibodies. As cornpared to the reactivities of the normal
proliferative endornetriurn, the glandular epithelial cells
were positive with NSE, S 100, virnentin and CEA,
but the strornal cells were only positive with vimentin.
Such a rnultitudinous and concornitant expression of
antigenicity to the different tumor elernents indicates a
close relationship to its rnesoderrnal Müllerian origin,
and NSE, S 100 and virnentin rnight be rnost adequate
indicators of these types of turnors.
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