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Effects of the prolonged administration of bradykinin on the rat pituitary-adrenocortical axis

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dc.contributor.authorMalendowicz, L.K.es
dc.contributor.authorMacchi, C.es
dc.contributor.authorNussdorfer, G.G.
dc.contributor.authorMarkowska, A.
dc.date.accessioned2011-02-22T10:32:59Z
dc.date.available2011-02-22T10:32:59Z
dc.date.issued1996
dc.description.abstractThe effects of a prolonged administration of bradykinin (BK) andlor D-Arg, [Hyp3, D - P ~ ~ ~ I - aB K , specific antagonist of BK receptors (BK-A) (daily subcutaneous injections of 4 nmol/rat for 6 days) on the function of the pituitary-adrenocortical axis were investigated. BK did not change plasma aldosterone concentration (PAC), but markedly lowered that of corticosterone (PBC) and consequently induced a compensatory hypersecretion of ACTH by the pituitary gland. BK-A did not apparently affect the function and growth of the adrenal gland, but, when administered together with BK, markedly raised both PAC and PBC, and provoked a significant atrophy of the adrenal gland, probably due to loss of parenchymal cells. Taken together, these rather puzzling findings do not appear to provide clear evidence for the involvement of BK in the physiological regulation of adrenocortical growth and steroidogenic capacity in rats.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18867
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectBradykinines
dc.subjectACTH secretiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomíaes
dc.titleEffects of the prolonged administration of bradykinin on the rat pituitary-adrenocortical axises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.11, nº 3 (1996)