Publication: Effects of the prolonged administration of bradykinin on the rat pituitary-adrenocortical axis
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Date
1996
Authors
Malendowicz, L.K. ; Macchi, C. ; Nussdorfer, G.G. ; Markowska, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of a prolonged administration of
bradykinin (BK) andlor D-Arg, [Hyp3, D - P ~ ~ ~ I - aB K ,
specific antagonist of BK receptors (BK-A) (daily
subcutaneous injections of 4 nmol/rat for 6 days) on the
function of the pituitary-adrenocortical axis were
investigated. BK did not change plasma aldosterone
concentration (PAC), but markedly lowered that of
corticosterone (PBC) and consequently induced a
compensatory hypersecretion of ACTH by the pituitary
gland. BK-A did not apparently affect the function and
growth of the adrenal gland, but, when administered
together with BK, markedly raised both PAC and PBC,
and provoked a significant atrophy of the adrenal gland,
probably due to loss of parenchymal cells. Taken
together, these rather puzzling findings do not appear to
provide clear evidence for the involvement of BK in the
physiological regulation of adrenocortical growth and
steroidogenic capacity in rats.
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Citation
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