Publication:
ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice

Simple item page
dc.contributor.authorHayashi, T.es
dc.contributor.authorHasegawa, K.es
dc.contributor.authorIchinohe, N.
dc.date.accessioned2011-06-30T11:59:41Z
dc.date.available2011-06-30T11:59:41Z
dc.date.issued2005
dc.description.abstractThe present study has examined relationship between cutaneous microvessel injury and adhesion molecule expression on the endothelium by cytokines in NZBxNZWF1 (B/WF1) mice, a model for human systemic lupus erythematosus. In advanced ages associated with overt clinical manifestation, but not in early ages, neutrophils with a minor proportion of monocytes and lymphocytes mainly adhered to the endothelium of capillary and the venule with fragmentation (leukocytoclasis), leading to the vascular injury (leukocytoclastic vasculitis). This was confirmed by the leak of monstral blue from the blood vessel. At this stage LFA-1+ leukocytes adhered to intensely expressed ICAM-1 on the endothelium, and this was paralleled with a significant rise in IL-1a and TNF-a in the circulation. The present study suggests that IL-1a and TNF-a may, at least in part, be responsible for the increased ICAM-1 expression on endothelium in cutaneous microvessels, resulting in the vascular injury characterized by neutrophilic leukocytoclasis in B/WF1 mice.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22432
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNeutrophiles
dc.subjectCytokinees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 micees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ICAM1 expression on endothelium and systemic.pdf
Size:
1.93 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.20, nº 1 (2005)