Publication: ICAM-1 expression on endothelium and systemic
cytokine production in cutaneous neutrophilic
leukocytoclastic vasculitis in NZBxNZWF1 mice
Authors
Hayashi, T. ; Hasegawa, K. ; Ichinohe, N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present study has examined relationship
between cutaneous microvessel injury and adhesion
molecule expression on the endothelium by cytokines in
NZBxNZWF1 (B/WF1) mice, a model for human
systemic lupus erythematosus. In advanced ages
associated with overt clinical manifestation, but not in
early ages, neutrophils with a minor proportion of
monocytes and lymphocytes mainly adhered to the
endothelium of capillary and the venule with
fragmentation (leukocytoclasis), leading to the vascular
injury (leukocytoclastic vasculitis). This was confirmed
by the leak of monstral blue from the blood vessel. At
this stage LFA-1+ leukocytes adhered to intensely
expressed ICAM-1 on the endothelium, and this was
paralleled with a significant rise in IL-1a and TNF-a in
the circulation. The present study suggests that IL-1a
and TNF-a may, at least in part, be responsible for the
increased ICAM-1 expression on endothelium in
cutaneous microvessels, resulting in the vascular injury
characterized by neutrophilic leukocytoclasis in B/WF1
mice.
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