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Increased endometrial expression of CC-chemokine receptor-1 in women with adenomyosis

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dc.contributor.authorXu, Hong
dc.contributor.authorYang, Yanfeng
dc.contributor.authorZhou, Caiyun
dc.contributor.authorHuang, Xiufeng
dc.contributor.authorLin, Jun
dc.contributor.authorZhang, Xinmei
dc.date.accessioned2019-09-27T14:01:14Z
dc.date.available2019-09-27T14:01:14Z
dc.date.issued2014
dc.description.abstractAbnormal endometrial expression of CCchemokine receptor-1 (CCR1) may play a role in the pathogenesis of endometriosis. Adenomyosis, also called endometriosis interna, occurs when the endometrium invades the myometrium. The objective of this study was to determine CCR1 expression in endometrium in women with adenomyosis as compared to women without adenomyosis. We evaluated endometrial mRNA and protein expression in women with and without adenomyosis using quantitative polymerase chain reaction (PCR), immunohistochemical staining and western blot analysis, respectively. We detected CCR1- immunoreactive expression in endometrium in all women with and without adenomyosis. CCR1- immunoreactive staining in endometrial cells was significantly higher in women with adenomyosis (4.89±1.06) compared to those without adenomyosis (2.21±1.16, P<0.001). Women with adenomyosis had higher levels of CCR1 mRNA in endometrium compared to women without adenomyosis (P<0.05). CCR1 protein levels in endometrium were significantly higher in women with adenomyosis (1.66±0.79) compared to women without adenomyosis (0.56±0.13, P<0.001), and positively correlated with the severity of dysmenorrhea (r=0.87, P<0.001). These results suggest that increased CC-chemokine receptor expression may play a role in the pathogenesis of adenomyosis.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 9, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/74948
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCC-chemokine receptor-1es
dc.subjectDysmenorrheaes
dc.subjectEndometriumes
dc.subjectAdenomyosises
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleIncreased endometrial expression of CC-chemokine receptor-1 in women with adenomyosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 9 (2014)