Publication: Increased endometrial expression of
CC-chemokine receptor-1 in women with adenomyosis
Authors
Xu, Hong ; Yang, Yanfeng ; Zhou, Caiyun ; Huang, Xiufeng ; Lin, Jun ; Zhang, Xinmei
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Abnormal endometrial expression of CCchemokine receptor-1 (CCR1) may play a role in the
pathogenesis of endometriosis. Adenomyosis, also called
endometriosis interna, occurs when the endometrium
invades the myometrium. The objective of this study
was to determine CCR1 expression in endometrium in
women with adenomyosis as compared to women
without adenomyosis. We evaluated endometrial mRNA
and protein expression in women with and without
adenomyosis using quantitative polymerase chain
reaction (PCR), immunohistochemical staining and
western blot analysis, respectively. We detected CCR1-
immunoreactive expression in endometrium in all
women with and without adenomyosis. CCR1-
immunoreactive staining in endometrial cells was
significantly higher in women with adenomyosis
(4.89±1.06) compared to those without adenomyosis
(2.21±1.16, P<0.001). Women with adenomyosis had
higher levels of CCR1 mRNA in endometrium compared
to women without adenomyosis (P<0.05). CCR1 protein
levels in endometrium were significantly higher in
women with adenomyosis (1.66±0.79) compared to
women without adenomyosis (0.56±0.13, P<0.001), and
positively correlated with the severity of dysmenorrhea
(r=0.87, P<0.001). These results suggest that increased
CC-chemokine receptor expression may play a role in
the pathogenesis of adenomyosis.
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Citation
Histology and Histopathology, vol. 29, nº 9, (2014)
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