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High expression of GPNMB predicts poor prognosis in head and neck squamous cell carcinoma

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dc.contributor.authorLi, Hao
dc.contributor.authorXiao, Yao
dc.contributor.authorWu, Cong Cong
dc.contributor.authorYang, Lei Lei
dc.contributor.authorCao, Ling Yun
dc.contributor.authorChen, De Run
dc.contributor.authorZhou, Jun Jie
dc.contributor.authorZhang, Wen Feng
dc.contributor.authorSun, Zhi Jun
dc.date.accessioned2022-07-05T08:47:55Z
dc.date.available2022-07-05T08:47:55Z
dc.date.issued2019
dc.description.abstractGlycoprotein non-metastatic protein B (GPNMB) is a transmembrane glycoprotein that is highly expressed in several malignancies compared with its expression in matched healthy tissues. The aim of this study was to investigate the clinical characteristics and prognostic value of GPNMB expression in tumor tissue derived from a cohort of patients with head and neck squamous cell carcinoma (HNSCC). GPNMB expression in human HNSCC, oral dysplasia and normal mucosal tissue was evaluated by immunohistochemistry (IHC). The correlations of GPNMB expression with the clinical characteristics of HNSCC were assessed by oneway ANOVA and t test analyses. Survival data were analyzed using Kaplan-Meier analysis and the Cox proportional hazards model. GPNMB was highly expressed in HNSCC tissue compared with dysplasia and normal mucosal tissue. Additionally, a high level of GPNMB expression in HNSCC was associated with poor prognosis (P<0.01). In the analysis of tumor-nodemetastasis (TNM) staging, a high GPNMB expression level in HNSCC tissue, as well as metastatic lymph node tissue, correlated with an advanced N stage. In conclusion, GPNMB was overexpressed in human HNSCC tissue and predicted poor prognosis in human HNSCC tissue. In addition, GPNMB expression was closely correlated with N stage in patients with HNSCC.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.34, nÂş7, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-084
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/122130
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGPNMBes
dc.subjectHead and neck squamous cell carcinomaes
dc.subjectPrognosises
dc.subjectTNM staginges
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleHigh expression of GPNMB predicts poor prognosis in head and neck squamous cell carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nÂş7 (2019)