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Myriad pillars formed by intussusceptive angiogenesis as the basis of intravascular papillary endothelial hyperplasia (IPEH). IPEH is intussusceptive angiogenesis made a lesion

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dc.contributor.authorDíaz-Flores, Lucio
dc.contributor.authorGutiérrez, Ricardo
dc.contributor.authorGonzález-Gómez, Miriam
dc.contributor.authorPino García, Mª
dc.contributor.authorCarrasco, José Luis
dc.contributor.authorDíaz-Flores, Lucio
dc.contributor.authorMadrid Cuevas, Juan Francisco
dc.date.accessioned2022-12-23T10:15:27Z
dc.date.available2022-12-23T10:15:27Z
dc.date.issued2021
dc.description.abstract. Intussusceptive angiogenesis (IA) is the process by which pre-existing blood vessels split, expand and remodel through intravascular pillar formation. In previous works, we studied the morphologic characteristics of intravascular papillary endothelial hyperplasia (IPEH) and suggested the participation of IA in the histogenesis of the lesion. Our current goal is to demonstrate that myriad papillae in IPEH are in fact myriad pillars, the hallmarks of IA. For this purpose, specimens of 14 cases of IPEH were used for conventional histologic techniques, immunohistochemistry and immunofluorescence in confocal microscopy. The studies showed the following pillar characteristics: a) structural composition by an endothelial cell (EC) cover and a connective core, b) characteristic pillar image and its appearance and disappearance in whole-mounted and series of individual views in confocal microscopy (requirements for pillar identification), c) arrangement in masses, alignments and meshes, and d) formation from vein intimal ECs, which extend and originate loops that encircle vein wall components (interstitial tissue structures: ITSs) and fibrin. The encircling ECs form the pillar cover and the encircled ITSs or fibrin form the initial core. Intraluminal endothelial bridges also originate from the vessel wall and from the pillars (nascent and thin pillars). In conclusion, the formation of myriad pillars, predominantly in veins, is the basis of IPEH. This lesion may therefore be considered an excessive expression of IA: IA becomes a lesion.es
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dc.format.extent12es
dc.identifier.citationHistology and Histopathology Vol. 36, nº2 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-292
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126787
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIntussusceptive angiogenesises
dc.subjectEndothelial cellses
dc.subjectVein wall vascularizationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMyriad pillars formed by intussusceptive angiogenesis as the basis of intravascular papillary endothelial hyperplasia (IPEH). IPEH is intussusceptive angiogenesis made a lesion
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication773c85c2-1260-4a4d-9543-f5a615648d71
relation.isAuthorOfPublication.latestForDiscovery773c85c2-1260-4a4d-9543-f5a615648d71
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Histology and histopathology Vol.36, nº2 (2021)