Publication: Myriad pillars formed by intussusceptive
angiogenesis as the basis of intravascular
papillary endothelial hyperplasia (IPEH). IPEH
is intussusceptive angiogenesis made a lesion
Authors
Díaz-Flores, Lucio ; Gutiérrez, Ricardo ; González-Gómez, Miriam ; Pino García, Mª ; Carrasco, José Luis ; Díaz-Flores, Lucio ; Madrid Cuevas, Juan Francisco
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-292
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info:eu-repo/semantics/article
Description
Abstract
. Intussusceptive angiogenesis (IA) is the
process by which pre-existing blood vessels split,
expand and remodel through intravascular pillar
formation. In previous works, we studied the
morphologic characteristics of intravascular papillary
endothelial hyperplasia (IPEH) and suggested the
participation of IA in the histogenesis of the lesion. Our
current goal is to demonstrate that myriad papillae in
IPEH are in fact myriad pillars, the hallmarks of IA. For
this purpose, specimens of 14 cases of IPEH were used
for conventional histologic techniques, immunohistochemistry and immunofluorescence in confocal
microscopy. The studies showed the following pillar
characteristics: a) structural composition by an
endothelial cell (EC) cover and a connective core, b)
characteristic pillar image and its appearance and
disappearance in whole-mounted and series of individual
views in confocal microscopy (requirements for pillar
identification), c) arrangement in masses, alignments and
meshes, and d) formation from vein intimal ECs, which
extend and originate loops that encircle vein wall
components (interstitial tissue structures: ITSs) and
fibrin. The encircling ECs form the pillar cover and the
encircled ITSs or fibrin form the initial core.
Intraluminal endothelial bridges also originate from the
vessel wall and from the pillars (nascent and thin
pillars). In conclusion, the formation of myriad pillars,
predominantly in veins, is the basis of IPEH. This lesion
may therefore be considered an excessive expression of
IA: IA becomes a lesion.
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Citation
Histology and Histopathology Vol. 36, nº2 (2021)
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