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Distribution of matrix metalloproteinases MMP-1, MMP-2, MMP-8 and tissue inhibitor of matrix metalloproteinases- 2 in nasal polyposis and chronic rhinosinusitis

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dc.contributor.authorEyibilen, Ahmet
dc.contributor.authorCayli, Sevil
dc.contributor.authorAladag, Ibrahim
dc.contributor.authorKoç, Sema
dc.contributor.authorGurbuzler, Levent
dc.contributor.authorAtay, Gulsen Arslan
dc.coverage.temporal1987-2008es
dc.date.accessioned2016-04-18T11:23:36Z
dc.date.available2016-04-18T11:23:36Z
dc.date.issued2011
dc.description.abstractSummary. Nasal polyposis (NP), a chronic inflammatory disease of the upper airway, is a subgroup of chronic rhinosinusitis (CRS). Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are considered to play important roles in the pathogenesis of nasal polyposis. The aim of the current study was to evaluate and compare the levels of MMP-1, MMP-2, MMP-8 and TIMP-2 in NP and CRS with normal nasal mucosa by using immunohistochemistry. Twenty-five patients with NP and fifteen patients with CRS underwent endoscopic sinus surgery. Diseased mucosal samples were obtained from ethmoidal sinuses. Control nasal mucosa (n=10) was obtained from inferior nasal turbinate. Immunohistochemistry for MMP-1, MMP-2, MMP-8 and TIMP-2 was performed. The expression of MMP-1, MMP-2 and MMP-8 significantly increased in NP and CRS compared with control (p<0.05). The distribution of TIMP-2 was higher in CRS than control and NP respectively (p<0.05). MMP-1 immunoreactivity was distributed in the extracellular matrix whereas MMP-2, MMP-8 and TIMP-2 immunostaining was present in the epithelium, submucosal glands, vascular endothelium and inflammatory cells in CRS and NP. We suggest that differences in histological features between CRS and NP might be related to the expression of MMP-1, MMP-2, MMP-8 and their tissue inhibitor-2.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/48634
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and Histopathology, vol.26, nº5, 2011es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMatrix metalloproteinase-1es
dc.subjectMatrix metalloproteinases-2es
dc.subjectMatrix metalloproteinases-8es
dc.subject.other61 - Medicinaes
dc.titleDistribution of matrix metalloproteinases MMP-1, MMP-2, MMP-8 and tissue inhibitor of matrix metalloproteinases- 2 in nasal polyposis and chronic rhinosinusitises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº5 (2011)