Publication: Distribution of matrix metalloproteinases MMP-1, MMP-2,
MMP-8 and tissue inhibitor of matrix metalloproteinases-
2 in nasal polyposis and chronic rhinosinusitis
Authors
Eyibilen, Ahmet ; Cayli, Sevil ; Aladag, Ibrahim ; Koç, Sema ; Gurbuzler, Levent ; Atay, Gulsen Arslan
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. Nasal polyposis (NP), a chronic
inflammatory disease of the upper airway, is a subgroup
of chronic rhinosinusitis (CRS). Matrix metalloproteinases
(MMPs) and their tissue inhibitors (TIMPs)
are considered to play important roles in the
pathogenesis of nasal polyposis. The aim of the current
study was to evaluate and compare the levels of MMP-1,
MMP-2, MMP-8 and TIMP-2 in NP and CRS with
normal nasal mucosa by using immunohistochemistry.
Twenty-five patients with NP and fifteen patients with
CRS underwent endoscopic sinus surgery. Diseased
mucosal samples were obtained from ethmoidal sinuses.
Control nasal mucosa (n=10) was obtained from inferior
nasal turbinate. Immunohistochemistry for MMP-1,
MMP-2, MMP-8 and TIMP-2 was performed. The
expression of MMP-1, MMP-2 and MMP-8 significantly
increased in NP and CRS compared with control
(p<0.05). The distribution of TIMP-2 was higher in CRS
than control and NP respectively (p<0.05). MMP-1
immunoreactivity was distributed in the extracellular
matrix whereas MMP-2, MMP-8 and TIMP-2
immunostaining was present in the epithelium,
submucosal glands, vascular endothelium and
inflammatory cells in CRS and NP. We suggest that
differences in histological features between CRS and NP
might be related to the expression of MMP-1, MMP-2,
MMP-8 and their tissue inhibitor-2.
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