Publication: Effect of dicarboxylic (C, and C,) acids on a human squamous carcinoma cell line in culture
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Date
1989
Authors
Pätzold, H. C. ; Breathnach, A. S. ; Robins, E. J. ; Daridan, M. E. ; Bhasin, Y. P. ; Ethridge, L. B. ; Nazzaro-Porro, M. ; Passi, S. ; Picardo, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In tissue culture, azelaic acid (C,) has been
shown to have an anti-proliferative and cytotoxic effect
on human and murine malignant melanocytes, with inhibition
of mitochondrial oxido-reductase enzymes and
DNA synthesis, and damage to mitochondria. Recent
reports of effects on differentiation of normal keratocytes
have led to the present study of its effects on a
squamous carcinoma cell line.
Cells were exposed to single doses of disodium
salts of azelaic (CY2Na) and adipic (C,2Na) acids at
concentrations of 10-,M and 5 x 10p2M for 48 hrs. Only
C,2Na at 5 x 1OP2M for 4 hrs., and longer, significantly
affected proliferation, and the cells exhibited massive
swelling 6f mitochondria with loss of cristae.
The results further confirm the probable value of
azelaic acid as a general anti-tumoral agent rather than a
specifically melanocytotoxic one. They could justify
clinical studies on the effect of topical azelaic acid
therapy on squamous cell carcinoma in vivo.
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