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Ets transcription factors in intestinal morphogenesis, homeostasis and disease

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dc.contributor.authorJedlicka, Paules
dc.contributor.authorGutierrez-Hartmann, Arthures
dc.date.accessioned2013-01-22T10:04:44Z
dc.date.available2013-01-22T10:04:44Z
dc.date.issued2008
dc.description.abstractEts transcription factors comprise a large family of sequence-specific regulators of gene expression with important and diverse roles in development and disease. Most Ets family members are expressed in the developing and/or mature intestine, frequently in a compartment-specific and temporally dynamic manner. However, with the exception of the highly expressed Elf3, involved in embryonic epithelial differentiation, little is known about Ets functions in intestinal development and homeostasis. Ets factors show altered expression in colon cancer, where they regulate pathways relevant to tumor progression. Ets factors also likely act as important modifiers of nonneoplastic intestinal disease by regulating pathways relevant to tissue injury and repair. Despite a large body of published work on Ets biology, much remains to be learned about the precise functions of this large and diverse gene family in intestinal morphogenesis, homeostasis, and both neoplastic and non-neoplastic pathology.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29859
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectIntestinees
dc.subjectCanceres
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleEts transcription factors in intestinal morphogenesis, homeostasis and diseasees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23,nº11 (2008)