Publication: Ets transcription factors in intestinal morphogenesis, homeostasis and disease
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Date
2008
Authors
Jedlicka, Paul ; Gutierrez-Hartmann, Arthur
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ets transcription factors comprise a large
family of sequence-specific regulators of gene
expression with important and diverse roles in
development and disease. Most Ets family members are
expressed in the developing and/or mature intestine,
frequently in a compartment-specific and temporally
dynamic manner. However, with the exception of the
highly expressed Elf3, involved in embryonic epithelial
differentiation, little is known about Ets functions in
intestinal development and homeostasis. Ets factors
show altered expression in colon cancer, where they
regulate pathways relevant to tumor progression. Ets
factors also likely act as important modifiers of nonneoplastic
intestinal disease by regulating pathways
relevant to tissue injury and repair. Despite a large body
of published work on Ets biology, much remains to be
learned about the precise functions of this large and
diverse gene family in intestinal morphogenesis,
homeostasis, and both neoplastic and non-neoplastic
pathology.
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