Publication: Ultrastructural alterations of the cortical epithelial cells of the rat thymus after cyclophosphamide treatment
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Date
1997
Authors
Yoon, S. ; Yoo, Y.H. ; Kim, B.S. ; Kim, J.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A single dose of cyclophosphamide (CY)
was administered to Sprague-Dawley rats to investigate
the effects of CY on thymic cortical epithelial cells
(TCE) at the ultrastructural level. The most striking
finding among the alterations in the TCE after CY
treatment was a cytoplasmic vacuolization with an
increased amount of granular and membranous content.
The granular content appeared not only as dense bodies
but also as loosely aggregated forms or finely dispersed
grandes. The membranous structures appeared in
various forms including vesicular, tubular, vacuolar and
irregular membranous structures and myelin figures.
Some of the membranous structures contained granular
material. Severa1 vacuoles were closely associated with
the endoplasmic reticulum (ER). The morphological
alterations of the ER were also remarkable. The Golgi
apparatus, mitochondria and vesicles increased in
number. The cytoplasm became densely granulated due
to an increased number of ribosomes and an increased
amount of granular material. The tonofilaments lost their
original array and increased in amount. The cell surface
exhibited many cytoplasmic processes like microvilli. It
seems that the above features result not only from some
damage by CY, but are also signs of a hyperfunctiona1
state of the TCE, probably due to their important
functions in repopulation and maturation of the cortical
thymocytes during recovery after CY-induced acute
thymic involution, including the secretion of some
humoral factors.
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