Publication: Fusion mechanism of the myoblasts in the myotome of the chick embryo
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Date
1993
Authors
González Santander, R. ; Toledo Lobo, M.V. ; Martínez Alonso, F.J. ; Martínez Cuadrado, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have studied the fusion process of
rnyoblasts in the mytome corresponding to H.H. stages
22, 23 and 24 from calcitonin-treated chick embryos and
their untreated controls. The micrograph images of this
process were studied to detect the ultrastructural changes
in myoblast morphology that could be associated with
the known hormonal and biochen~ical changes that take
place in preparation of fusion. Once actin and myosin
myofilament differentiation and sarcomerogenesis
had begun, the myotome myoblasts fused in bundles
of 10- 14 myoblasts, and the following was observed
during this process: plasmatic membrane interdigitation
and invagination; the appearance of cytoplasmic
flaps covering other myoblasts and fading at the point
of contact; plasmatic membranes that fade and
disintegrate; membrane rupturing; double closed lamina;
small ringed lamina; large disperse vesicles; small
vesicles (liposomes), and semi-dense amorphous
material. Seven stages were established: 1.- Membrane
rupture; 2.- Double closed and elongated lamina; 3.-
Small ringed lamina aligned lengthwise; 4.- Large
dispersed vesicles; 5.- Imprecise boundaries with
a~norphous material in diffuse areas; 6.- Cytoplasm
fusion; and 7.- Prefunctional syncitium.
Answers to the questions: <<how,,, <<when,,, <<where,,,
<<why,)a nd <<fowr hat purpose>>t he fusion of myoblasts
takes place are suggested.
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