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From Barrett metaplasia to esophageal adenocarcinoma: the molecular background

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dc.contributor.authorSaraggi, Deborah
dc.contributor.authorFassan, Matteo
dc.contributor.authorBornschein, Jan
dc.contributor.authorFarinati, Fabio
dc.contributor.authorRealdon, Stefano
dc.contributor.authorValeri, Nicola
dc.contributor.authorRugge, Massimo
dc.date.accessioned2021-03-04T12:51:07Z
dc.date.available2021-03-04T12:51:07Z
dc.date.issued2016
dc.description.abstractThe molecular landscape of Barrett’s esophagus and Barrett-related neoplastic lesions is still far from being completely elucidated. Both in vitro and in vivo studies pinpointed the pathogenetic role of different morphogenic pathways (the para-homeobox, the Notch and the Sonic Hedgehog families in particular) implicated in the acquisition of the metaplastic phenotype of the esophageal mucosa. On the other hand, the most common genetic alterations observed during Barrett's carcinogenesis include disorders of major regulators of the cell cycle, as well as deregulation of the TGF-β/Smad and receptor tyrosine kinases signalling pathways. Recent comprehensive mutational profiling studies identified that the inactivation of the TP53 and of the SMAD4 tumour suppressor genes occurred in a stage-specific manner, confined to (high grade) dysplastic and neoplastic lesions, respectively. The next step will be the correlation of these findings into multidisciplinary diagnostic approaches integrating endoscopy, histology, molecular profiling and liquid biopsies. This will allow the introduction of innovative strategies for secondary prevention of esophageal adenocarcinoma based on biological rationales, and the implementation of potential novel therapeutic targets.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, vol.31, nº 1, (2016)
dc.identifier.doi10.14670/HH-11-659
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/104263
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBarrett’s esophaguses
dc.subjectMolecular pathologyes
dc.subjectBiomarkerses
dc.subjectMicroRNAes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleFrom Barrett metaplasia to esophageal adenocarcinoma: the molecular backgroundes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nº1 (2016)