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Trypanosoma cruzi infection patterns in intact and athymic mice of susceptible and resistant genotypes

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dc.contributor.authorGonçalves da Costa, S.C.es
dc.contributor.authorCalabrese, K.S.es
dc.contributor.authorZaverucha do Valle, T.
dc.contributor.authorLagrange, P.H.
dc.date.accessioned2011-05-11T10:58:27Z
dc.date.available2011-05-11T10:58:27Z
dc.date.issued2002
dc.description.abstractInbred strains of mice inoculated with the T. cruzi Y strain behaved as susceptible (A/J, C3H/HeN), intermediate (BALB/c) or relatively resistant (C57BL/6) with respect to the magnitude of parasitaemia and mortality rate. C57BL/10 mice were susceptible in relation to parasitaemia but resistant when mortality was analyzed. Infection with T. cruzi CL strain presented the same results, except for C57BL/6 which behaved as susceptible mice. Athymic mice of various backgrounds revealed no differences in susceptibility, presenting the same dramatic parasitaemia, tissue colonization pattern and no inflammatory reaction in any of the tissues studied. Infection of euthymic and athymic BALB/c mice elicited the production of parasite-specific antibodies, which reached similar levels on the first 9 days but differed after day 13. Serum transfer experiments in BALB/c mice did not show great differences in parasitaemia but altered T. cruzi polymorphism reducing the slender forms in athymic mice. Histopathology of athymic BALB/c mice showed the same tissue tropism when infected either with T. cruzi Y or CL strain.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20806
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectSusceptibilityes
dc.subjectResistancees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleTrypanosoma cruzi infection patterns in intact and athymic mice of susceptible and resistant genotypeses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.17, nº 3 (2002)