Publication: Hyperplastic innervation of vasoactive intestinal peptide in human gallbladder with cholelithiasis
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Date
1995
Authors
Gonda, T. ; Akiyoshi, H. ; Ichihara, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The vasoactive intestinal peptide (VIP)
immunoreactive nerve fibres in the gallbladder from 14
human patients with cholelithiasis was examined by
immunohistochemical method. In the chronic cholecystitis,
hyperplastic VIP immunoreactive nerves were
observed around the hypertrophied muscle bundles,
Rokitansky Aschoff Sinus and in the mucosal layer.
However, in the acute cholecystitis and gangrenous
cholecystitis, reduction or disappearance of VIP nerve
fibres was observed. These reductions or disappearances
of VIP immunoreactive nerves may secondly result from
severe tissue damage. These results suggest that
hyperplastic VIP nerves cause gallbladder relaxation,
stasis and mucosal fluid unbalance, which may closely
correlate to gallstone formation.
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Citation
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