Publication: Age-related morphometric changes occurring in the somata of astrocytes of the granular layer of rat neocerebellar cortex (Crus I and Crus II)
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Date
1992
Authors
Monteiro, R.A.F. ; Rocha, E. ; Marini-Abreu, M.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A quantitative study conceming the agerelated
changes occurring in the cell body and somatic
organelles of neocerebellar astrocytes is carried out,
using rats aged 2 to 24 months. Manual stereological
techniques are used to determine the following
parameters on electron micrographs: the somatic
volume, the volume density and the absolute volume of
the protoplasmic structures as well as the mean surface
of the rough endoplasmic reticulum cisternae per
cell.None of the pararneters reveals any clear-cut general
temporal pattern. The soma and the cell components
show statistically significant differences in the
parameters with ageing, excepting the dense bodies
(relative and absolute volumes) and the Golgi apparatus
(relative volume). There are significant positive linear
trends between, on the one hand, the somatic volume
and, on the other hand, the absolute volume of either of
the following structures: nucleus, glial filaments,
ground substance and dense bodies. Some linear
correlations between the absolute volumes of organelles
are also found. Despite the ability for karyokinesis, it is
concluded that astrocytes do undergo changes with
ageing.
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