Development and economic evaluation of an eco-friendly biocatalytic
synthesis of emollient esters.

Serrano-Arnaldos, A.; Montiel, M.C.; Ortega Requena, Salvadora; Máximo, F.; Bastida, J.

Publication:
Development and economic evaluation of an eco-friendly biocatalytic synthesis of emollient esters.

dc.contributor.author	Serrano-Arnaldos, A.
dc.contributor.author	Montiel, M.C.
dc.contributor.author	Ortega Requena, Salvadora
dc.contributor.author	Máximo, F.
dc.contributor.author	Bastida, J.
dc.contributor.department	Ingeniería Química
dc.date.accessioned	2024-01-31T10:08:42Z
dc.date.available	2024-01-31T10:08:42Z
dc.date.created	2019
dc.description	©<2020>. This manuscript version is made available under the CC-BY-NC-ND license http://creativecommons.org/licenses/ccby-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in [Bioprocess and Biosystems Engineering]. To access the final edited and published work see [https://doi.org/ 10.1007/s00449-019-02243-1]
dc.description.abstract	During the last decades the understanding and prospects of enzyme-catalysed reactions have been massively widened and there are a number of implemented large-scale enzymatic processes mainly based in the use of commercial biocatalysts. As it might happen that the same process can be successfully carried out by different commercial lipases, the election of the biocatalyst must rely on productivity and economic considerations. This work presents productiveness and direct operation cost evaluation as a key tool for the selection between two commercial lipase catalysts, the versatile but expensive Novozym® 435 and a much more economical option, Lipozyme® TL IM, in the synthesis of spermaceti, a mixture of emollient esters with cosmetic applications. Proving that Novozym® 435 leads to minimum savings of 10% with respect to the cheapest immobilized derivative, biocatalyst cost does not appear to be the major contribution to the economics of the processes under study, due to their great capacity to be recovered and reused. At laboratory scale, the biggest economic investment is caused by substrates, which can be massively reduced at industrial scale by using bulk reagents. In such case, energy cost may be the major contribution to the process economy. This work proposes an optimized process ready to be scaled-up in order to accurately determine the energetic requirements of the possible industrial enzymatic synthesis.	es
dc.format	application/pdf	es
dc.format.extent	26	es
dc.identifier.citation	Bioprocess and Biosystems Engineering, Volume 325, 10 January 2021, Pages 91-99
dc.identifier.doi	https://doi.org/10.1007/s00449-019-02243-1
dc.identifier.issn	Print: 1615-7591
dc.identifier.issn	Electrónico: 1615-7605
dc.identifier.uri	http://hdl.handle.net/10201/138280
dc.language	eng	es
dc.publisher	Springer
dc.relation	Organismo financiador: Ministerio de Ciencia, Innovación y Universidades. Convocatoria: Proyectos Retos de Investigación 2015. Proyecto: DESARROLLO DE BIOPROCESOS SOSTENIBLES PARA LA OBTENCIÓN DE INGREDIENTES COSMÉTICOS ETIQUETABLES COMO "NATURALES". Código: CTQ2015-66723-R. M. Serrano-Arnaldos and S. Ortega-Requena fueron beneficiarias de una beca predoctoral FPI y una beca Torres Quevedo del Ministerio de España de Economia y Competitividad (MINECO).	es
dc.relation.publisherversion	https://link.springer.com/article/10.1007/s00449-019-02243-1	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Candida antarctica	es
dc.subject	Cost assessment	es
dc.subject	Solvent-free	es
dc.subject	Spermaceti	es
dc.subject	Thermomyces lanuginosus	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::54 - Química
dc.title	Development and economic evaluation of an eco-friendly biocatalytic synthesis of emollient esters.	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es