Publication: Development and economic evaluation of an eco-friendly biocatalytic
synthesis of emollient esters.
Authors
Serrano-Arnaldos, A. ; Montiel, M.C. ; Ortega Requena, Salvadora ; Máximo, F. ; Bastida, J.
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Publisher
Springer
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DOI
https://doi.org/10.1007/s00449-019-02243-1
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info:eu-repo/semantics/article
Description
©<2020>. This manuscript version is made available under the CC-BY-NC-ND license http://creativecommons.org/licenses/ccby-nc-nd/4.0/
This document is the Accepted version of a Published Work that appeared in final form in [Bioprocess and Biosystems Engineering]. To access the final edited and published work see [https://doi.org/ 10.1007/s00449-019-02243-1]
Abstract
During the last decades the understanding and prospects of enzyme-catalysed reactions
have been massively widened and there are a number of implemented large-scale enzymatic
processes mainly based in the use of commercial biocatalysts. As it might happen that the
same process can be successfully carried out by different commercial lipases, the election
of the biocatalyst must rely on productivity and economic considerations. This work
presents productiveness and direct operation cost evaluation as a key tool for the selection
between two commercial lipase catalysts, the versatile but expensive Novozym® 435 and a
much more economical option, Lipozyme® TL IM, in the synthesis of spermaceti, a mixture
of emollient esters with cosmetic applications. Proving that Novozym® 435 leads to
minimum savings of 10% with respect to the cheapest immobilized derivative, biocatalyst
cost does not appear to be the major contribution to the economics of the processes under
study, due to their great capacity to be recovered and reused. At laboratory scale, the
biggest economic investment is caused by substrates, which can be massively reduced at
industrial scale by using bulk reagents. In such case, energy cost may be the major
contribution to the process economy. This work proposes an optimized process ready to be
scaled-up in order to accurately determine the energetic requirements of the possible
industrial enzymatic synthesis.
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Citation
Bioprocess and Biosystems Engineering, Volume 325, 10 January 2021, Pages 91-99
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