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Rab GTPases in the differential processing of phagocytosed pathogens versus efferocytosed apoptotic cells

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dc.contributor.authorTaefehshokr, Nima
dc.contributor.authorYin, Charles
dc.contributor.authorHeit, Bryan
dc.date.accessioned2022-12-22T11:44:00Z
dc.date.available2022-12-22T11:44:00Z
dc.date.issued2021
dc.description.abstractPhagocytosis is an important feature of innate immunity in which invading microorganisms are engulfed, killed and degraded - and in some immune cells, their antigens presented to the adaptive immune system. A closely related process, efferocytosis, removes apoptotic cells, and is essential for the maintenance of homeostasis. Both phagocytosis and efferocytosis are tightly regulated processes that involve target recognition and uptake through specific receptors, followed by endolysosomal trafficking and processing of the internalized target. Central to the uptake and trafficking of these targets are the Rab family of small GTPases, which coordinate the engulfment and trafficking of both phagocytosed and efferocytosed materials through the endolysosomal system. Because of this regulatory function, Rab GTPases are often targeted by pathogens to escape phagocytosis. In this review, we will discuss the shared and differential roles of Rab GTPases in phagocytosis and efferocytosis.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology Vol. 36, nº2 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-252
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126746
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPhagocytosises
dc.subjectEfferocytosises
dc.subjectRab GTPasees
dc.subjectPhagosomees
dc.subjectEfferosomees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleRab GTPases in the differential processing of phagocytosed pathogens versus efferocytosed apoptotic cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº2 (2021)