Publication:
Rab GTPases in the differential processing of phagocytosed pathogens versus efferocytosed apoptotic cells

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Taefehshokr-36-123-135-2021.pdf(1.81 MB)
Date
2021
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Authors
Taefehshokr, Nima ; Yin, Charles ; Heit, Bryan
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-252
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info:eu-repo/semantics/article
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Abstract
Phagocytosis is an important feature of innate immunity in which invading microorganisms are engulfed, killed and degraded - and in some immune cells, their antigens presented to the adaptive immune system. A closely related process, efferocytosis, removes apoptotic cells, and is essential for the maintenance of homeostasis. Both phagocytosis and efferocytosis are tightly regulated processes that involve target recognition and uptake through specific receptors, followed by endolysosomal trafficking and processing of the internalized target. Central to the uptake and trafficking of these targets are the Rab family of small GTPases, which coordinate the engulfment and trafficking of both phagocytosed and efferocytosed materials through the endolysosomal system. Because of this regulatory function, Rab GTPases are often targeted by pathogens to escape phagocytosis. In this review, we will discuss the shared and differential roles of Rab GTPases in phagocytosis and efferocytosis.
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Phagocytosis , Efferocytosis , Rab GTPase , Phagosome , Efferosome
Citation
Histology and Histopathology Vol. 36, nº2 (2021)
URI
http://hdl.handle.net/10201/126746
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Histology and histopathology Vol.36, nº2 (2021)
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