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Consistent lack of CD34-positive stromal cells in the stroma of malignant breast lesions

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dc.contributor.authorKuroda, Naotoes
dc.contributor.authorJin, Y.L.es
dc.contributor.authorHamauzu, T.
dc.contributor.authorToi, M.
dc.contributor.authorMiyazaki, E.
dc.contributor.authorHiroi, Makoto
dc.contributor.authorMoriki, T.
dc.contributor.authorEnzan, H.
dc.date.accessioned2011-06-30T12:00:33Z
dc.date.available2011-06-30T12:00:33Z
dc.date.issued2005
dc.description.abstractTo examine the distribution of CD34-positive and ASMA-positive stromal cells in various breast lesions, we performed immunohistochemical assays (using a streptavidin-biotin immunoperoxidase technique) of tissue specimens, obtained by excisional biopsy and partial or total mastectomy, from 62 patients with breast lesions. Specimens were obtained from 64 lesions as follows: fibrocystic disease (n=12), intraductal papilloma (n=4), fibroadenoma (n=17), invasive lobular carcinoma (n=6), invasive ductal carcinoma (n=20) and invasive micropapillary carcinoma (n=5). In normal breast tissue (controls), CD34-positive spindle cells were abundant in the intralobular stroma, but no ASMApositive stromal cells were identified except myoepithelial cells. Small to large numbers of CD34- positive cells were observed in the stroma of 29 of 33 benign diseases. In all invasive carcinomas (lobular, ductal and micropapillary), no CD34-positive stromal cells were observed in the stroma. In the stroma of benign lesions, the number of ASMA-positive stromal cells was various, but the stroma of all invasive breast cancers contained ASMA-positive stromal cells. The present results indicate that disappearance of CD34- positive stromal cells consistently occurs in the stroma of invasive carcinoma of the breast, irrespective of histological type and may be associated with the presence of ASMA-positive stromal cells.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22497
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectBreast canceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleConsistent lack of CD34-positive stromal cells in the stroma of malignant breast lesionses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 3 (2005)