Publication: Consistent lack of CD34-positive stromal
cells in the stroma of malignant breast lesions
Authors
Kuroda, Naoto ; Jin, Y.L. ; Hamauzu, T. ; Toi, M. ; Miyazaki, E. ; Hiroi, Makoto ; Moriki, T. ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
To examine the distribution of CD34-positive
and ASMA-positive stromal cells in various breast
lesions, we performed immunohistochemical assays
(using a streptavidin-biotin immunoperoxidase
technique) of tissue specimens, obtained by excisional
biopsy and partial or total mastectomy, from 62 patients
with breast lesions. Specimens were obtained from 64
lesions as follows: fibrocystic disease (n=12), intraductal
papilloma (n=4), fibroadenoma (n=17), invasive lobular
carcinoma (n=6), invasive ductal carcinoma (n=20) and
invasive micropapillary carcinoma (n=5). In normal
breast tissue (controls), CD34-positive spindle cells were
abundant in the intralobular stroma, but no ASMApositive
stromal cells were identified except
myoepithelial cells. Small to large numbers of CD34-
positive cells were observed in the stroma of 29 of 33
benign diseases. In all invasive carcinomas (lobular,
ductal and micropapillary), no CD34-positive stromal
cells were observed in the stroma. In the stroma of
benign lesions, the number of ASMA-positive stromal
cells was various, but the stroma of all invasive breast
cancers contained ASMA-positive stromal cells. The
present results indicate that disappearance of CD34-
positive stromal cells consistently occurs in the stroma
of invasive carcinoma of the breast, irrespective of
histological type and may be associated with the
presence of ASMA-positive stromal cells.
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