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Usefulness of Genotype MTBDRplus assay in acid-fast bacilli positive smear specimens in Almeria, Spain

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dc.contributor.authorMartínez-Lirola, Miguel José
dc.contributor.authorMuñoz-Dávila, María José
dc.contributor.authorGarcía-de Viedma, Darío
dc.contributor.authorCabezas Fernández, Teresa
dc.contributor.authorLuzón García, Pilar
dc.contributor.authorIndal-Tb Group
dc.contributor.departmentGenética y Microbiología
dc.coverage.spatialAlmería
dc.date.accessioned2025-09-18T11:17:54Z
dc.date.available2025-09-18T11:17:54Z
dc.date.issued2014-05-05
dc.description© 2013 Elsevier España.___ This document is the published version of a published work that appeared in final form in Enfermedades infecciosas y microbiologia clinica (English ed.)___ To access the final edited and published work see: http://dx.doi.org/10.1016/j.eimc.2014.02.017
dc.description.abstracttIntroduction: The urgent need for operational research evaluating test performance in a real-world settinghas been highlighted. The purpose of this study was therefore to evaluate the performance of MTBDRplusassay.Materials: According to the reference method, of the 155 clinical specimens with valid results, 147 weresusceptible to rifampicin (RIF) and isoniazid (INH), with 4 being multi-drug resistant (MDR) and 4 withisolated resistance to isoniazid (INH).Results: The results of the MTBDRplus assay were 100% concordant for the MDR and mono-resistantto INH specimens. However, the MTBDRplus assay showed a resistance pattern to RIF in one specimenwhich was classified as susceptible by the reference method. The majority of the specimens (118/75.6%)were also tested using the MTBDRplus method after culture on Lowenstein-Jensen media, showing 100%agreement with the results of the test directly from the specimens. An MTBDRplus test result was availablewithin an average of 8 days.Conclusions: Overall, MTBDR results showed excellent results when compared with the reference methodand achieved a significant time-reduction.
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dc.identifier.citationEnfermedades infecciosas y microbiologia clinica (English ed.) 2014 32(8):511–514
dc.identifier.doihttp://dx.doi.org/10.1016/j.eimc.2014.02.017
dc.identifier.eissnElectronic.: 2529-993X
dc.identifier.urihttps://hdl.handle.net/10201/158769
dc.languageeng
dc.publisherElsevier Doyma
dc.relationThis study was partially supported by the Juntade Andalucía (PI-0444/2008 and PI-0306/2009) and the SEPAR(Spanish Society of Pneumology and Thoracic Surgery) (763/2009).
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0213005X14000871?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMolecular susceptibility
dc.subjectComparison
dc.subjectReducción tiempo de respuesta
dc.subjectGenotype MTBDRplus
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleUsefulness of Genotype MTBDRplus assay in acid-fast bacilli positive smear specimens in Almeria, Spain
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
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