Publication: The role of focal adhesion Kinase in early development
Authors
Chatzizacharias, Nikolaos A. ; Kouraklis, Gregory P. ; Theocharis, Stamatios E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
FAK is a tyrosine kinase enzyme
demonstrated to play an important regulatory role in
several basic cellular activities. Scientific evidence have
suggested that FAK possessing a central position in the
integrin signaling cascade, is responsible, at least in part,
for the modulation of cellular proliferation, protection
from apoptosis, adhesion, spreading and migration. The
role of FAK in the development of different species,
including human, is under study. Various published data
supported the role of the molecule in the development of
the placenta, as well as of several organ systems, like the
musculoskeletal, nervous, cardiovascular, genitourinary
and respiratory organ systems. Additionally, FAK has
been shown to be implicated in the pathophysiology of
pregnancy related disorders and congenital neonatal
diseases and defects. The purpose of this article is a
comprehensive review of the existing literature with a
view to the future and the potential conclusions that can
be drawn by the study of FAK signaling on the events of
early life and species development.
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