Publication: Mechanisms of Bcl-2 protein function
Authors
Wang, H.G. ; Reed, J.C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Bcl-2 protein blocks a distal step in an
evolutionarily conserved pathway for programmed cell
death and apoptosis. The gene encoding this protein was
first discovered because of its involvement in the
t(14;18) chromosomal translocations commonly found in
B-cell lymphomas. Overexpression of Bcl-2 also occurs
in many other types of human cancers, and prevents cell
death induced by nearly all anticancer drugs and
radiation. Since the discovery of Bcl-2 over ten years
ago, several cellular and viral homologs have been
identified, some of which suppress cell death and others
which promote apoptosis. Many of these proteins can
interact with each other through a complex network of
homo- and heterodimers. Though functionally important,
dimerization events still do not explain in a broader
sense how these proteins actually control cell life and
death. Recent findings that Bcl-2 can function both as an
ion channel and as an adapter or docking protein
however are beginning to provide insights into the
molecular mechanisms through which these proteins
regulate the programmed cell death pathway in normalcy
and disease.
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