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Intestinal uptake of amyloid B protein through columnar epithelial cells in suckling mice

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dc.contributor.authorAno, Yasuhisaes
dc.contributor.authorNakayama, Hiroyukies
dc.contributor.authorSakudo, Akikazu
dc.contributor.authorSawano, Yoriko
dc.contributor.authorTanokura, Masaru
dc.contributor.authorItohara, Shigeyoshi
dc.contributor.authorOnodera, Takashi
dc.date.accessioned2013-09-24T11:33:50Z
dc.date.available2013-09-24T11:33:50Z
dc.date.issued2009
dc.description.abstractThe mechanism of transmission of amyloid protein, especially the dynamics in the intestine, is still largely unknown. In the present study, a fusion protein (Aß-EGFP) that combined enhanced green fluorescent protein with amyloid-ß protein (Aß) was orally administered to mice before and after weaning, and the uptake and kinetics of amyloid protein within the intestine were elucidated through histopathology. Aß- EGFP was incorporated into the cytoplasm of columnar epithelial cells, rather than M cells, at 3 h after administration and thereafter. Aß-EGFP then accumulated in the crypt, Peyer's patch, and even the spleen. However, this uptake was not observed in weaned mice. These results suggest that a specific tolerant mechanism for incorporation of Aß escaped from the digestion exists during suckling periods. This age-dependent uptake is important for estimating the risk of transmission.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/35999
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyen_EN
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAmyloidosisen_EN
dc.subjectColumnar epithelial cellsen_EN
dc.subject.other636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticoses
dc.titleIntestinal uptake of amyloid B protein through columnar epithelial cells in suckling miceen_EN
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24, nº3 (2009)