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Glypican-3 (GPC3) expression in human placenta: localization to the differentiated syncytiotrophoblast

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dc.contributor.authorKhan, S.es
dc.contributor.authorBlackburn, M.es
dc.contributor.authorMao, D.L.
dc.contributor.authorHuber, R.
dc.contributor.authorSchlessinger, D.
dc.contributor.authorFant, M.
dc.date.accessioned2011-05-11T10:55:35Z
dc.date.available2011-05-11T10:55:35Z
dc.date.issued2001
dc.description.abstractThe expression of glypican-3 (GPC3), a heparan-sulfate proteoglycan associated with the Simpson-Golabi-Behmel fetal overgrowth syndrome, was studied in normal human placental tissue and cell lines derived from human placentae. Cytotrophoblasts derived from term placentae expressed GPC3 mRNA at low levels in culture. GPC3 mRNA expression increased markedly during trophoblast differentiation. By contrast, fibroblast cell lines derived from normal placentae did not express GPC3 in culture. Similarly, choriocarcinoma cell lines derived from human placentae (BeWo, JAR, and JEG) failed to express GPC3 mRNA. In situ hybridization confirmed the localization of GPC3 mRNA to the syncytiotrophoblast. Furthermore, immunohistochemical staining of paraffin imbedded placental tissue demonstrated intense staining of the syncytiotrophoblast cell layer and less intense staining of cytotrophoblasts. No staining of mesenchymal elements was noted. These data confirm the presence of GPC3 in human placenta and suggest it is expressed by the differentiated syncytiotrophoblast at termes
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20639
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPlacentaes
dc.subjectGlypican-3es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleGlypican-3 (GPC3) expression in human placenta: localization to the differentiated syncytiotrophoblastes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.16, nº 1 (2001)