Bruton’s Tyrosine Kinase is 
involved in innate and adaptive immunity

Publication:
Bruton’s Tyrosine Kinase is involved in innate and adaptive immunity

dc.contributor.author	Brunner, C.	es
dc.contributor.author	Müller, B.	es
dc.contributor.author	Wirth, T.
dc.date.accessioned	2011-06-30T12:00:38Z
dc.date.available	2011-06-30T12:00:38Z
dc.date.issued	2005
dc.description.abstract	Btk is a cytoplasmic tyrosine kinase, which is mainly involved in B cell receptor signalling. Gene targeting experiments revealed that Btk is important for B cell development and function. However, Btk is not only expressed in B cells, but also in most other haematopoietic lineages except for T cells and plasma cells. Recently we found that Btk is involved in Toll-like receptor signalling. Toll-like receptors play an important role in innate immunity. They are highly expressed on mast cells, macrophages and dendritic cells, which are essential for the recognition and consequently for the elimination of microbial pathogens. Therefore Btk might play an important role for the function of immunocompetent cells of innate as well as adaptive immunity.	es
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/22503
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	B cells	es
dc.subject	Myeloid cells	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Bruton’s Tyrosine Kinase is involved in innate and adaptive immunity	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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