Publication: Bruton’s Tyrosine Kinase is
involved in innate and adaptive immunity
Authors
Brunner, C. ; Müller, B. ; Wirth, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Btk is a cytoplasmic tyrosine kinase, which
is mainly involved in B cell receptor signalling. Gene
targeting experiments revealed that Btk is important for
B cell development and function. However, Btk is not
only expressed in B cells, but also in most other
haematopoietic lineages except for T cells and plasma
cells. Recently we found that Btk is involved in Toll-like
receptor signalling. Toll-like receptors play an important
role in innate immunity. They are highly expressed on
mast cells, macrophages and dendritic cells, which are
essential for the recognition and consequently for the
elimination of microbial pathogens. Therefore Btk might
play an important role for the function of
immunocompetent cells of innate as well as adaptive
immunity.
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