Publication: Enzyme histochemistry of corneal wound healing
Authors
Cejkova, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The usefulness of enzyme histochemical
methods for the localization of enzymes as catalysts of
molecular interactions in the cells and tissues of healing
corneal wounds is shown in rabbits. The current data on
corneal wound healing in humans as well as in rabbits
with particular reference to serine proteases are
reviewed. Some inflammatory mediators are also
discussed. Plasmin is a serine protease which is absent
(or present only in very low concentration) in the tear
fluid, and its activity appears under various pathological
conditions in humans or following experimental injuries
in rabbits. The role of increasing plasmin activity in the
tear fluid in the depending upon the severity of corneal
injury is evaluated. Great attention is devoted to
conditions leading to long-lasting elevated levels of
plasmin activity in the tear fluid correlated with corneal
ulceration. The differences between the histochemical
pattern of untreated corneas or corneas treated with some
serine protease inhibitors are shown, and the efficacy of
these drugs is discussed in light of present knowledge.
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