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Hepatocyte growth factor/scatter factor and prostate cancer: a review

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dc.contributor.authorHurle, R.A.es
dc.contributor.authorDavies, Grahames
dc.contributor.authorParr, C.
dc.contributor.authorMason, M.D.
dc.contributor.authorJenkins, S.A.
dc.contributor.authorKynaston, H.G.
dc.contributor.authorJiang, W.G.
dc.date.accessioned2011-06-30T12:01:02Z
dc.date.available2011-06-30T12:01:02Z
dc.date.issued2005
dc.description.abstractMen who die from prostate cancer do so from uncontrolled metastatic disease. A better understanding of the mechanisms involved in the progression and metastasis of prostate cancer may lead to novel therapeutic approaches to prevent its natural progression. Hepatocyte Growth Factor / Scatter factor (HGF/SF) has been demonstrated to elicit a number of key functions in numerous tissues that are important in the progression, invasion and metastasis of cancer. Studies have demonstrated that the activity of HGF/SF and its receptor c-Met are linked to disease progression in numerous cancers. However, research into these functions, which include activities as a mitogen, a motogen and an anti-apoptotic and angiogenic factor in prostate cancer are limited. This article reviews the published evidence of the roles HGF/SF plays in prostate cancer progression and highlights the clinical and therapeutic potential of research into this pleiomorphic cytokine.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22534
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHepatocyte growth factores
dc.subjectProstate canceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.6 - Patología del sistema genitourinarioes
dc.titleHepatocyte growth factor/scatter factor and prostate cancer: a reviewes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 4 (2005)