Publication: Hepatocyte growth factor/scatter factor and prostate cancer: a review
Authors
Hurle, R.A. ; Davies, Graham ; Parr, C. ; Mason, M.D. ; Jenkins, S.A. ; Kynaston, H.G. ; Jiang, W.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Men who die from prostate cancer do so
from uncontrolled metastatic disease. A better
understanding of the mechanisms involved in the
progression and metastasis of prostate cancer may lead
to novel therapeutic approaches to prevent its natural
progression. Hepatocyte Growth Factor / Scatter factor
(HGF/SF) has been demonstrated to elicit a number of
key functions in numerous tissues that are important in
the progression, invasion and metastasis of cancer.
Studies have demonstrated that the activity of HGF/SF
and its receptor c-Met are linked to disease progression
in numerous cancers. However, research into these
functions, which include activities as a mitogen, a
motogen and an anti-apoptotic and angiogenic factor in
prostate cancer are limited. This article reviews the
published evidence of the roles HGF/SF plays in prostate
cancer progression and highlights the clinical and
therapeutic potential of research into this pleiomorphic
cytokine.
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