Publication: Chemopreventive effects of NSAlDs against colorectal cancer, regulation of apoptosis and mitosis by COX-1 and COX-2
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Date
1998
Authors
Watson, A.J.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
There is a wealth of evidence that nonsteroidal
anti-inflammatory drugs (NSAIDs) can prevent
colorectal cancer. In this article the role of cyclooxygenase
1 and 2, the principle target of NSAIDs, in
the development of colorectal cancer is reviewed.
Cyclooxygenase is constituitevely expressed in normal
colonic epithelium and surrounding stroma and could
catalyse the generation of malondialdehyde which is a
known mutagen and could initiate colorectal carcinogenesis.
Mutation of APC which is an early genetic
event leads to the expression of cyclooxygenase 2 which
may prevents the appropriate apoptosis of mutant
adenoma cells. Other proneoplastic effects of cyclooxygenase
include changing the action of Transforming
Growth Factor l3 from anti-proliferative to proproliferative,
reducing adherence to extracellular matrix,
promotes metastasis and angiogenesis. These properties
of cyclooxygenases suggest that inhibition of both
isoforms may have important protective effects against
colorectal cancer.
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Citation
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