Publication: How bad is brazilian ginseng extract for reproductive parameters in mice?
Authors
Dias, F.C.R. ; Machado Neves, M. ; Lima, G.D.A. ; Martins, A.L.P. ; Menezes, T.P. ; Melo, F.C.S.A. ; Gomes, M.L.M. ; Cupertino, M.C. ; Otoni, W.C. ; Matta, S.L.P.
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
http://doi.org/10.14670/HH-18-244
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info:eu-repo/semantics/article
Description
Abstract
Properties attributed to the Panax ginseng
are also attributed to the Brazilian ginseng, such as
adaptogenic and aphrodisiac effects. There are studies
demonstrating that the Brazilian ginseng (BGE) possibly
increases the serum levels of testosterone and nitric
oxide in mice and rats. The present study aimed to
evaluate the effects of its extract on male fertility and
sperm quality. Male Swiss mice (n=60) were divided
into six groups. The control animals were provided 0.5
mL of water, and 0.5 mL of water containing 7 mg/kg
per day (d) sildenafil citrate. Other animals were treated
with BGE at 100 mg/kg/d, 200 mg/kg/d, and 400
mg/kg/d by gavage for 42 days. Finally, animals from
the last group received 200 mg/kg BGE every 3 days (3-
3d) by gavage for 42 days. The results showed a
reduction in the number of resistant spermatids in the
testis and damage to daily sperm production,
culminating in a reduction in the number of epididymal
spermatozoa. Although the sperm quality decreased in
all experimental animals, only males treated with BGE
100 mg/kg/d showed pre and post implantation embryo
losses. We concluded that BGE alters sperm viability
compromising the embryonic development after
implantation
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Citation
Histology and Histopathology Vol. 35, nº10 (2020)
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