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MiR-29c-3p represses gastric cancer development via modulating MEST

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dc.contributor.authorLi, Honghai
dc.contributor.authorLv, Jieqing
dc.contributor.authorWang, Jindao
dc.contributor.authorWang, Haifeng
dc.contributor.authorLuo, Liang
dc.date.accessioned2023-05-03T09:57:52Z
dc.date.available2023-05-03T09:57:52Z
dc.date.issued2023
dc.description.abstractGastric cancer (GC) triggers a great number of deaths worldwide. Although great efforts have been made in treating this cancer, GC patients’ survival rate remains unsatisfactory. An increasing amount of evidence indicates that miR-29c-3p inhibits cancer progression. However, the mechanism of miR-29c-3p in GC remains to be fully defined. Hence, this work aimed to analyze the underlying mechanism of miR-29c-3p in GC. Outcomes showed marked downregulation of miR29c-3p in GC tissue and cell lines. Functional experiments exhibited that miR-29c-3p repressed GC cell malignant behaviors. Moreover, bioinformatics analysis and dual-luciferase reporter gene detection indicated that MEST was targeted by miR-29c-3p. Rescue assay further proved that MEST participated in functions of miR-29c-3p in GC. To sum up, miR-29c3p/MEST signaling pathway suppressed formation of malignant phenotypes of GC, and targeting the signaling pathway may be a new method for treating GC.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and Histopathology Vol. 38, nÂş5 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-537
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/130614
dc.languageenges
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGastric canceres
dc.subjectmiR-29c-3pes
dc.subjectMESTes
dc.subjectProliferationes
dc.subjectInvasiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleMiR-29c-3p represses gastric cancer development via modulating MESTes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nÂş5 (2023)