Publication: MiR-29c-3p represses gastric cancer development via modulating MEST
Authors
Li, Honghai ; Lv, Jieqing ; Wang, Jindao ; Wang, Haifeng ; Luo, Liang
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Publisher
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DOI
https://doi.org/10.14670/HH-18-537
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info:eu-repo/semantics/article
Description
Abstract
Gastric cancer (GC) triggers a great number
of deaths worldwide. Although great efforts have been
made in treating this cancer, GC patients’ survival rate
remains unsatisfactory. An increasing amount of
evidence indicates that miR-29c-3p inhibits cancer
progression. However, the mechanism of miR-29c-3p in
GC remains to be fully defined. Hence, this work aimed
to analyze the underlying mechanism of miR-29c-3p in
GC. Outcomes showed marked downregulation of miR29c-3p in GC tissue and cell lines. Functional
experiments exhibited that miR-29c-3p repressed GC
cell malignant behaviors. Moreover, bioinformatics
analysis and dual-luciferase reporter gene detection
indicated that MEST was targeted by miR-29c-3p.
Rescue assay further proved that MEST participated in
functions of miR-29c-3p in GC. To sum up, miR-29c3p/MEST signaling pathway suppressed formation of
malignant phenotypes of GC, and targeting the signaling
pathway may be a new method for treating GC.
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Citation
Histology and Histopathology Vol. 38, nÂş5 (2023)
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Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/