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Radix Actinidiae chinensis inhibits neovascularization in colorectal cancer and its mechanism

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dc.contributor.authorMinyuan Chen
dc.contributor.authorJiante Li
dc.contributor.authorJieyu Liu
dc.contributor.authorZiqi Meng
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biología Celular e Histología
dc.date.accessioned2026-03-25T16:33:33Z
dc.date.available2026-03-25T16:33:33Z
dc.date.issued2026
dc.description.abstractObjective. Colorectal cancer is one of the most common cancers worldwide, and its angiogenesis is a key factor in tumor growth and metastasis. Radix Actinidiae chinensis is considered to have antitumor activity in traditional Chinese medicine, but its effect on neovascularization in colorectal cancer has not been clarified. Herein, we aimed to evaluate the effect of different concentrations of Radix Actinidiae chinensis on the neovascularization of colorectal cancer and explore its possible mechanisms. Method. A mouse model of colorectal cancer was established, and mice were randomly divided into control, low-, and high-concentration groups. Then the mice in the experimental group were treated with Radix Actinidiae chinensis, and its effects on neovascularization and tumor growth were evaluated by tumor growth curve tracking, immunohistochemical analysis, vessel density assessment, RT-qPCR, and protein immunoblotting to explore the underlying mechanisms. Results. It was shown that tumor tissues in the high concentration group exhibited significantly slower growth in both mass and volume compared with the low concentration and control groups. Immunohistochemical staining revealed a reduction in the expression of the vascular endothelial marker CD31 in the Radix Actinidiae chinensis treatment group. Moreover, the protein expression levels of vascular markers in tumor tissues showed a slight decrease in the low-concentration group and a marked reduction in the high-concentration group. These findings suggest that angiogenesis in the tumor microenvironment was inhibited in a concentration-dependent manner, with protein expression levels closely mirroring gene expression patterns. Conclusion. The study found that Radix Actinidiae chinensis inhibits neovascularization in a dose dependent manner in a mouse model of colorectal cancer. These results provide experimental support for its potential use as a therapeutic agent against colorectal cancer, suggesting that it may suppress tumor growth and metastasis by inhibiting angiogenesis.
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dc.format.extent9
dc.identifier.doihttps://doi.org/10.14670/HH-18-977
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/223042
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRadix Actinidiae chinensis
dc.subjectNeovascularization
dc.subjectAngiogenesis
dc.subjectTumor growth
dc.subjectColorectal cancer
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleRadix Actinidiae chinensis inhibits neovascularization in colorectal cancer and its mechanism
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº4, (2026)