Publication: lmmunoreactivity for c-fos and c-myc protein with the monoclonal antibodies 14E10 and 6E10 in malignant mesothelioma and nonneoplastic mesothelium of the pleura
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Date
1995
Authors
Ramael, M. ; Van den Bossche, J. ; Buysse, C. ; Deblier, I. ; Segers, K. ; Van Marck, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We studied immunoreactivity for c-fos
protein and c-myc protein in malignant mesothelioma
(36 cases) and non-neoplastic pleural mesothelium (45
cases) using the murine monoclonal antibodies 14E10
and 6E10. All malignant mesotheliomas and cases with
non-neoplastic mesothelium exhibited not only nuclear
but also cytoplasmic immunoreactivity for c-fos and cmyc
protein in the majority of mesothelial cells. There
was no statistically significant difference between the
various mesothelioma subtypes or between neoplastic
and non-neoplastic mesothelium for c-fos protein
immunoreactivity (p>0.05). There was statistically
significant difference between neoplastic and nonneoplastic
mesothelium for c-myc protein immunoreactivity
(p<0.0 1).
We conclude that immunoreactivity for c-fos and cmyc
protein is present in both non-neoplastic and
neoplastic mesothelium, but that a higher proportion of
neoplastic mesothelial cells are immunoreactive for cmyc
protein when compared with non-neoplastic
mesothelium.
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