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Immunohistochemical study of human pterygium

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dc.contributor.authorPerra, M. T.es
dc.contributor.authorMaxia, C.es
dc.contributor.authorZucca, I.
dc.contributor.authorPiras, F.
dc.contributor.authorSirigu, P.
dc.date.accessioned2011-05-11T10:57:48Z
dc.date.available2011-05-11T10:57:48Z
dc.date.issued2002
dc.description.abstractThe purpose of this study has been to evaluate the immunohistochemical characteristics of human pterygial tissues in order to ascertain the possible contribution of an immunological mechanism in the pathogenesis of pterygium and to investigate the presence in the pterygial tissues of some melanomaassociated antigens, in order to evaluate if there may be a small possibility of correlation of the two diseases. Human biopsy specimens of pterygium were obtained by surgery for pterygium excision. Ti s s u e segments were fixed and processed for paraf f i n embedding. Microtome sections were treated for the immunohistochemical demonstration of IgA, IgM, IgG, CD3, CD20, CD68, HLA-DR, Protein S100, HMB45, and Melan A using the avidin-biotin peroxidase method or the streptavidin biotin-alkaline phosphatase method. The findings suggest that all the effector components of the mucosal immune system are present in the human pterygium and, among the most sensitive markers for melanoma, only S100 shows immunoreactivity. An immunopathogenetic mechanism seems to be responsible for the pathogenesis of pterygium, perhaps being caused by pre-existing conjunctivitis or microtrauma in combination with the patient’s predisposition. No correlation between pterygium and melanoma was found.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20765
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectImmune systemes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleImmunohistochemical study of human pterygiumes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.17, nº 1 (2002)