Publication: Immunohistochemical study of human pterygium
Authors
Perra, M. T. ; Maxia, C. ; Zucca, I. ; Piras, F. ; Sirigu, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The purpose of this study has been to
evaluate the immunohistochemical characteristics of
human pterygial tissues in order to ascertain the possible
contribution of an immunological mechanism in the
pathogenesis of pterygium and to investigate the
presence in the pterygial tissues of some melanomaassociated
antigens, in order to evaluate if there may be
a small possibility of correlation of the two diseases.
Human biopsy specimens of pterygium were
obtained by surgery for pterygium excision. Ti s s u e
segments were fixed and processed for paraf f i n
embedding. Microtome sections were treated for the
immunohistochemical demonstration of IgA, IgM, IgG,
CD3, CD20, CD68, HLA-DR, Protein S100, HMB45,
and Melan A using the avidin-biotin peroxidase method
or the streptavidin biotin-alkaline phosphatase method.
The findings suggest that all the effector components
of the mucosal immune system are present in the human
pterygium and, among the most sensitive markers for
melanoma, only S100 shows immunoreactivity.
An immunopathogenetic mechanism seems to be
responsible for the pathogenesis of pterygium, perhaps
being caused by pre-existing conjunctivitis or
microtrauma in combination with the patient’s
predisposition. No correlation between pterygium and
melanoma was found.
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