Publication: Nonerythroid membrane skeletal
proteins in normal and diseased human skin
Authors
Shimizu, T. ; Takakuwa, Y. ; Koizumi, H. ; Ohkawara, A.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
A number of reports have described the
presence and localization of membrane skeletal proteins
in nonerythroid tissues and cultured cells. Interactions
of these proteins, which have been extensively
characterized in erythrocytes, may be physiologically
important in other cell types. This review focuses on
recent developments concerning proteins analogous to
erythrocyte spectrin, protein 4.1, adducin and ankyrin in
epidermal keratinocytes, and discusses their significance
from physiological and pathological stand points.
Keratinocyte proteins are involved in a wide variety of
functions such as the cell-to-cell and cell-to-substratum
adhesion, stratification, and maintenance of the cell
shape. In epidermal keratinocytes, these nonerythroid
membrane skeletal proteins may play a role in
maintaining the polarity of membrane proteins by
connecting them to the cytoskeleton, regulating cell-cell
interdigitations and stabilizing newly synthesized cell
membranes before elaboration of cell-cell interdigitations.
Furthermore, altered expression and
distribution of these proteins may be important in the
pathogenesis of skin disease such as psoriasis.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.